Anti?inflammatory activities of <i>Gardenia jasminoides</i> extracts in retinal pigment epithelial cells and zebrafish embryos

Age?related macular degeneration (AMD) is the most common cause of visual impairment in developed countries. Inflammation serves a critical role pathogenesis AMD. Gardenia jasminoides found several regions China and traditionally used as an organic yellow dye but has also been widely therapeutic agent numerous diseases, including inflammation, depression, hepatic vascular disorders, which may reflect variability functional compounds that are present extracts (GJE). To investigate potential GJE for AMD, ARPE?19 cells were treated with lipopolysaccharide (LPS) or LPS plus GJE. significantly decreased LPS?induced expression proinflammatory cytokines, IL?1?, IL?6 TNF??. In in vivo study, inhibited CuSO4?induced migration primitive macrophages to lateral line zebrafish embryos. attenuated cytokines (IL?1?, TNF??), NFKB activating protein (nkap) TLR4 cells. The results study demonstrated anti?inflammatory vitro and vivo, suggested candidate